شیوع سرولوژیکی هپاتیت های ویروسی C , B , A در کارکنان بهداشتی - درمانی و واکسیناسیون افراد حساس به عفونت در بیمارستان بوعلی ساری 1382

Background and purpose : Health care workers (HCW,s) are at increased risk of hepatitis viruses infection .Seroprevalence rates of hepatitis B and C viruses ( HBV,HCV) are higher among HCWs .Universal precautions to prevent the transmission of infections during medical cares along with vaccination are recommended or even mandatory in most countries. The purpose of this study was to determine the seroprevalence of anti-HAV , anti–HCV ,and anti-HBs antibodies,and HBV vaccination status in a general teaching hospital HCWs in Sari-Iran . Materials and methods : Between June to October 2003, questionnaire was used, data extracted from medical records, and serology by ELISA method for anti-HAV, anti-HBs anti-HCV, and-HBs-Ag in those HCWs with negative anti-HBs. HBV vaccination status were recorded . Seroprovalence rates of HBs-Ag and anti-HCV antibody were compared with those detected in blood donors during the same period. Results : Totally 263 HCWs and 17 kitchen staff were participated in the study. Anti –HAV, anti-HBs , anti-HCV ,and HBs-Ag were detected in 90.36% ,87.5% ,0.37% and 0.74% of the subjects respectively. HBs-Ag and anti-HCV were detected in 4.8% and 0.83% of blood donors, respectively. 61.9 % of HCWs completed their HBV vaccine series and 72.7% of non-vaccinated HCWs developed anti-HBs antibody. Conclusion : These data showed that the prevalence of HBs-Ag and anti-HCV in HCWs was lower than general population. HAV infection was hyperendemic. HBV infection was higher among non-vaccinated personnel, and more than 1/3 of HCWs did not complete their vaccination, so, mandatory HBV vaccination, is recommended.